beta Catenin (CTNNB1) Mouse Monoclonal Antibody [Clone ID: 9F2]
CAT#: AM26372PU-N
beta Catenin (CTNNB1) mouse monoclonal antibody, clone 9F2, Purified
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CNY 5,729.00
Cited in 2 publications. |
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Specifications
Product Data | |
Clone Name | 9F2 |
Applications | FC, IF, IP, WB |
Recommend Dilution | Flow cytometry. Immunoflourescence (cells fixed in paraformaldehyde): The typical starting working dilution is 1:10. Immunoprecipitation (cells fixed in paraformaldehyde). Western blot (cells fixed in paraformaldehyde): The typical starting working dilution is 1:10. |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Specificity | This antibody detects Beta-Catenin. |
Formulation | PBS State: Purified State: Liquid 0.2 µm filtered Ig fraction Stabilizer: 0.1% bovine serum albumin Preservative: 0.02% sodium azide |
Concentration | lot specific |
Purification | Protein G |
Conjugation | Unconjugated |
Storage Condition | Store at 2 - 8 °C. |
Gene Name | catenin beta 1 |
Database Link | |
Background | Beta-catenin belongs together with alpha- and gamma-catenin to the catenin family. Catenins mediates cell-cell adhesion by interaction with cadherins. Beta-catenin is highly homologous to gamma-catenin (plakoglobin) although its function differs from that of plakoglobin. Whereas plakoglobin has been found to suppress tumorigenicity, beta-catenin potentiates hyperproliferation and tumor formation. In the nucleus beta-catenin it complexes with transcription factors and thus regulates the expression of specific genes. By its dual role, i.e. a structural role in cell-cell junctions and a regulatory role in the nucleus, beta-catenin can transduce changes in cell adhesion and junction formation to control transmembrane signalling and gene expression. |
Synonyms | CTNNB1, CTNNB, Beta-catenin |
Reference Data |
Citations (2)
The use of this Antibodies has been cited in the following citations: |
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XAV939 inhibits the proliferation and migration of lung adenocarcinoma A549 cells through the WNT pathway
,null,
Oncology Letters
,PubMed ID 29805633
[CTNNB1]
|
Orai1 mediates osteogenic differentiation via BMP signaling pathway in bone marrow mesenchymal stem cells
,null,
Biochemical and biophysical research communications
,PubMed ID 27086849
[CTNNB1]
|
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