LBP Mouse Monoclonal Antibody [Clone ID: 1C7]

Specifications

Product Data
Clone Name	1C7
Applications	ELISA, FN, IP
Recommend Dilution	Functional assays. ELISA both as coating and detector. Immunoprecipitation. Not useful for immunohistology neither for Western blotting.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Specificity	The monoclonal antibody 1C7 reacts highly specific with human natural and recombinant LBP. Crossreactions with LBP of other species are not observed. The antibody binds poorly to LBP-LPS complexes: it interacts with the LPS binding site.
Formulation	PBS State: Purified State: Liquid 0.2 µm filtered Ig fraction Stabilizer: 0.1% bovine serum albumin Preservative: containing 0.02% sodium
Concentration	lot specific
Purification	Protein G
Conjugation	Unconjugated
Storage Condition	Store at 2 - 8 °C.
Gene Name	lipopolysaccharide binding protein
Database Link	NP_004130.2 Entrez Gene 3929 Human UniProt ID P18428
Background	LPS binding protein (LBP) is an approximately 60 kDa acute phase protein that is produced by hepatocytes. This protein strongly binds to LPS and has been shown to play an important role in the handling of LPS by the host. A number of functions of LBP have been reported. First, LBP transfers LPS to the LPS receptor CD14 on mononuclear phagocytes, leading to an 100-1,000 fold increased sensitivity of the cells to LPS. Furthermore, LBP can enhance the response of CD14 negative cells by acceleration of LPS binding to soluble CD14, a complex that stimulates these cells. Next, LBP transfers LPS into High Density Lipoprotein (HDL), which effectively neutralizes its biological potency. LBP was demonstrated to protect mice from septic shock caused by LPS or gram negative bacteria.
Synonyms	Lipopolysaccharide-binding protein
Reference Data
Protein Families	Druggable Genome, Secreted Protein
Protein Pathways	Toll-like receptor signaling pathway

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