Complement C3 (C3) Mouse Monoclonal Antibody [Clone ID: 474]
CAT#: AM26263BT-N
Complement C3 (C3) mouse monoclonal antibody, clone 474, Biotin
Conjugation: Unconjugated
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CNY 4,077.00
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Specifications
Product Data | |
Clone Name | 474 |
Applications | ELISA, WB |
Recommend Dilution | Immunoassay (1-3). Western blot (3): Diabetic serum proteins were separated on PAGE-gel and transferred to nitrocellulose. The typical starting working dilution is 1:50. Positive control: Human serum. Negative control: Serum of C3 deficient patients. |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | C3a |
Specificity | Monoclonal antibody 474 reacts with an epitope on C3a. The antibody reacts both with intact C3 as with C3a. |
Formulation | PBS Label: Biotin State: Liquid 0.2 µm filtered Stabilizer: 0.1% bovine serum albumin Preservative: 0.02% sodium azide |
Concentration | lot specific |
Purification | Potein G |
Conjugation | Biotin |
Storage Condition | Store at 2 - 8 °C. |
Gene Name | complement component 3 |
Database Link | |
Background | The complement system is an important factor in innate immunity. The third complement component, C3, is central to the classical, alternative and lectin pathways of complement activation. The synthesis of C3 is tissue-specific and is modulated in response to a variety of stimulatory agents. During complement activation, C3 is proteolytically cleaved resulting in release of the anaphylatoxic peptide C3a. C3a is a small polypeptide consisting of 74 amino acids (ca.10kDa). C3a itself is very short-lived and in serum cleaved rapidly into the more stable C3a-desArg (also called acylation stimulating protein, ASP) . C3a exerts its function through a specific receptor (C3aR), which belongs to the G-protein coupled receptor family. Expression of C3aR has been reported in many cell types including myeloid and non-myeloid cells. Expression of C3aR on haematopoietic stem/progenitor cells has been shown to promote the trafficking/homing of these cells to the BM. Engagement of C3aR on DCs and T cells has been shown to up-regulate these cell functions. |
Synonyms | CPAMD1, Complement component 3 |
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