CD71 (TFRC) Mouse Monoclonal Antibody [Clone ID: 3B8 2A1]

Specifications

Product Data
Clone Name	3B8 2A1
Applications	ELISA, IHC, IP, WB
Recommend Dilution	Immunohistochemistry on frozen sections: The typical starting working dilution is 1:10. Flow cytometry: The typical starting working dilution is 1:10. Immunoassay (detector). Immunprecipitation. Western blot: The typical starting working dilution is 1:10. The antibody does not inhibit the biological activity of TfR1.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Specificity	This antibody detects Transferrin receptor 1.
Formulation	PBS State: Purified State: Liquid 0.2 µm filtered Ig fraction Stabilizer: 0.1% bovine serum albumin Preservative: 0.02% sodium azide
Concentration	lot specific
Purification	Protein G
Conjugation	Unconjugated
Storage Condition	Store at 2 - 8 °C.
Gene Name	transferrin receptor
Database Link	Entrez Gene 7037 Human UniProt ID P02786
Background	Human transferrin receptor 1 (TfR1), also designated CD71, is a homodimeric type II membrane glycoprotein of 90-95 kDa. This receptor binds two molecules of the serum iron-transport protein transferrin (Tf) and is internalised into endosomes that are acidified, resulting in the release of iron from Tf. TfR1 is not expressed on resting leukocytes but is upregulated on all proliferating cells upon activation, reflecting the iron dependence of proliferation. In tissues TfR1 is expressed on most dividing cells and on brain capillary endothelium. Expression of TfR1 is down regulated as a result of iron overload. TfR1 shares 45% identity with TfR2.
Synonyms	TfR1, p90, Transferrin receptor protein 1
Reference Data

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.