C3AR1 Mouse Monoclonal Antibody [Clone ID: 17]

Specifications

Product Data
Clone Name	17
Applications	IHC
Recommend Dilution	Immunohistochemistry on frozen sections. Flow cytometry. The typical starting working dilution is 1:50.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Specificity	This antibody reacts with the receptor for C3a. It does not block binding of ligand to C3aR.
Formulation	PBS State: Purified State: Liquid 0.2 µm filtered Ig fraction Stabilizer: 0.1% bovine serum albumin Preservative: 0.02% sodium azide
Concentration	lot specific
Purification	Protein G
Conjugation	Unconjugated
Storage Condition	Store at 2 - 8 °C.
Gene Name	complement component 3a receptor 1
Database Link	Entrez Gene 719 Human UniProt ID Q16581
Background	In the course of complement activation the C3a receptor functions as the cell surface receptor for the anaphylatoxin C3a, the C-terminal 77 amino acid cleavage product of the alpha chain of C3, but not for C3a-desArg. All cellular responses to C3a are specifically mediated by interactions with the membrane bound C3a receptor, a seven transmembrane GTP-binding-protein-coupled receptor that belongs to the rhodopsin supergene family. The 54 kDa C3a receptor is widely distributed in, myeloid cells, peripheral tissues and the central nervous system. Expression of C3aR has been demonstrated on neutrophils, monocytes, eosinophils, astrocytes, neurons and glial cells and is increased in inflammatory conditions. No C3aR expression was detectable on lymphocytes and on tonsillar B cells even after stimulation.
Synonyms	C3a-R, C3AR, C3AR1, AZ3B, C3R1, HNFAG09
Note	The monoclonal antibody 17 is in the literature also referred to as clone hC3aRZ8.
Reference Data

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