chp (C-term) Mouse Monoclonal Antibody [Clone ID: JCC1]

Specifications

Product Data
Clone Name	JCC1
Applications	ELISA, FN, IHC, WB
Recommend Dilution	Immuno-assays Flow cytometry (1:10 as starting dilution). Western blot (1:100 as starting dilution). Immunohistology on frozen and paraffin sections (1:100 as starting dilution). Inhibition of biological activity. Before use in biological assays, the product must be filter sterilized and depending on the concentration to be used dialyzed against culture medium to remove the sodium azide added.
Reactivity	Staphylococcus aureus
Host	Mouse
Clonality	Monoclonal
Specificity	This antibody detects with the C-terminus of CHIPS.
Formulation	PBS State: Purified State: Liquid 0.2 µm filtered Ig fraction Stabilizer: 0.1% BSA Preservative: 0.01% sodium azide
Concentration	lot specific
Purification	Protein G purified
Conjugation	Unconjugated
Storage Condition	Product should be stored at 2-8 °C. Under recommended storage conditions, product is stable for one year.
Database Link	UniProt ID Q6GFB3
Background	The bacterial pathogen Staphylococcus aureus is insensitive to antimicrobial host defense peptides such as defensins, protegrins, platelet microbicidal proteins and bacteriocins. Staphylococci have developed various resistance mechanisms including those specific for bacteriocins and several host defense peptides. A protein belonging to the resistance mechanism of Staphylococcus aureus is known as CHIPS (Chemotaxis Inhibiting Protein of Staphylococcus aureus). CHIPS is a protein produced by Staphylococcus aureus that inhibits chemotaxis of neutrophils by blocking the Formyl Peptide Receptor (FPR) and C5a Receptor on neutrophils. CHIPS and antibodies against CHIPS can be useful for various experimental infection models of Staphylococcus aureus. Furthermore these reagents can be of help in studies on the role of FPR and C5a in inflammatory processes.
Reference Data

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