Integrin alpha E (ITGAE) Mouse Monoclonal Antibody [Clone ID: Ber-ACT8]

CAT#: AM26142PU-N

Integrin alpha E (ITGAE) mouse monoclonal antibody, clone Ber-ACT8, Aff - Purified

Conjugation: Unconjugated APC FITC PE



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CNY 3,140.00


货期*
5周

规格
    • 100 ug

Product images

Specifications

Product Data
Clone Name Ber-ACT8
Applications FC, IHC, IP, WB
Recommend Dilution Flow cytometry.
Immunoprecipitation.
Western blot.
Immunohistochemistry (frozen sections).
Reactivity Human, Primate
Host Mouse
Clonality Monoclonal
Immunogen HTLV-1 induced human T cell line MAPS16
Specificity This antibody recognizes CD103 (alpha E integrin), a type I transmembrane glycoprotein primarily found on intestinal intraepithelial lymphocytes.
Formulation Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
State: Aff - Purified
State: Liquid Ig fraction
Concentration lot specific
Purification Protein-A affinity chromatography (> 95% pure by SDS-PAGE)
Conjugation Unconjugated
Storage Condition Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 to -70 °C for longer. Avoid repeated freezing and thawing.
Gene Name integrin subunit alpha E
Background CD103 / Integrin alphaE is an integrin subunit that is expressed on intraepithelial lymphocytes, epithelial dendritic cells, lamina propria-derived dendritic cells, a subpopulation of lamina propria T cells, a small subset of peripheral lymphocytes, namely T reg cells, and on activated and TGF-beta stimulated lymphocytes. CD103 is in mature form cleaved into two disulfide-linked chains (C-terminal 150 kDa chain and N-terminal 25 kDa chain). It heterodimerizes with integrin beta7 subunit to form alphaE/beta7 integrin (mucosal lymphocyte 1 antigen), which through binding E-cadherin mediates homing of lymphocytes to the intestinal epithelium, and, in addition to the role in adhesion, may serve as an accessory molecule for intraepithelial lymphocyte activation.
Synonyms Integrin alpha-E, Integrin alpha-IEL, HML-1 antigen, ITGAE
Reference Data
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
Protein Pathways Regulation of actin cytoskeleton
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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