LY75 (LY75-CD302) Mouse Monoclonal Antibody [Clone ID: HD30]

Specifications

Product Data
Clone Name	HD30
Applications	FC, IHC, WB
Recommend Dilution	Flow cytometry. Western blot (only non-denatured samples). Immunohistochemistry (frozen sections).
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant Fc-tagged human CD205
Specificity	This antibody recognizes CD205, an approx. 200 kDa C-type lectin transmembrane protein of the MMR (macrophage mannose receptor) family, expressed at high levels on dendritic cells and thymic epithelial cells, and at low levels on lymphocytes, NK cells and monocytes.
Formulation	Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 State: Aff - Purified State: Liquid Ig fraction
Concentration	lot specific
Purification	Protein-A affinity chromatography; purity > 95% (by SDS-PAGE)
Conjugation	Unconjugated
Storage Condition	Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Gene Name	LY75-CD302 readthrough
Database Link	Entrez Gene 100526664 Human UniProt ID O60449
Background	CD205, also known as DEC-205, is an endocytic receptor of macrophage mannose receptor family. This 205 kDa C-type lectin transmembrane protein mediates adsorptive uptake and its intracellular domain contains coated pit localization sequence and distal acidic motif, which is required for recycling beyond early endosomes through deeper MHC II+ late endosomes and lysosomes. This unique pathway of receptor-mediated uptake proves to be necessary for presentation of antigenic peptides at low doses of ligand. CD205 is responsible for uptake and processing of captured antigens for dendritic cells.
Synonyms	LY75, CLEC13B, DEC205, gp200-MR6
Reference Data

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.