CD71 (TFRC) Mouse Monoclonal Antibody [Clone ID: SOM4D10]

Specifications

Product Data
Clone Name	SOM4D10
Applications	FC, IHC
Recommend Dilution	Immunohistochemistry on frozen sections: 1-3 μg/ml (1:130 - 1:400). Has been described to work in FACS. Suggested positive control: Human tonsil.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Specificity	This antibody recognizes the human CD71 antigen, the transferrin receptor.
Formulation	Stock solution contains 0.4mg/ml IgG, phosphate buffered saline pH 7.2 (PBS), 5mg/ml bovine serum albumin (BSA), and 0.09% sodium azide as a preservative State: Aff - Purified State: Lyophilized Ig fraction
Reconstitution Method	Reconstitute by adding 0.5 ml distilled water.
Purification	Affinity chromatography
Conjugation	Unconjugated
Storage Condition	Prior to reconstitution store at 2-8°C. Following reconstitution store (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Gene Name	transferrin receptor
Database Link	Entrez Gene 7037 Human UniProt ID P02786
Background	CD71 is a proliferation-associated homodimeric membrane glycoprotein consisting of two disulfide-bonded 95kD chains. CD71 is a type II membrane protein with short aminoterminal cytoplasmic domain which mediates internalization and recycling, a single transmembrane region, and a large extracellular transferrin-binding domain. CD71 contains N-linked and O-linked glycans, as well as palmitic acid covalently attached to cysteine residues close to the cytoplasmic face of the membrane.
Synonyms	TfR1, p90, Transferrin receptor protein 1
Note	Antigen distribution: Isolated cells: The antibody stains > 90% of activated human peripheral blood lymphocytes in flow cytometry. Tissue sections: Germinal center; basal layer of epidermis; tissue macrophages; testis.
Reference Data
Protein Families	Druggable Genome, ES Cell Differentiation/IPS, Protease, Secreted Protein, Transmembrane
Protein Pathways	Endocytosis, Hematopoietic cell lineage

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