KIR2DL4 Mouse Monoclonal Antibody [Clone ID: mAb#33]

Specifications

Product Data
Clone Name	mAb#33
Applications	FC
Recommend Dilution	Flow Cytometry analysis of human blood cells using 10 μl reagent / 100 μl of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	NK3.3 cells and KIR2DL4-Ig fusion protein
Specificity	This antibody (also known as mAb 33 or 33) recognizes extracellular portion of CD158d / KIR2DL4, a 45 kDa NK cell marker. Cell surface expression and function of CD158d / KIR2DL4 depends on genotype of particular individuals.
Formulation	Phosphate buffered saline (PBS) Label: APC State: Liquid purified Ig fraction Stabilizer: 0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA) Preservative: 15 mM sodium azide
Conjugation	APC
Storage Condition	Store the antibody undiluted at 2-8°C. DO NOT FREEZE! This product is photosensitive and should be protected from light.
Gene Name	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4
Database Link	Entrez Gene 3805 Human UniProt ID Q99706
Background	CD158d / KIR2DL4 is a KIR family member that shares structural features with both activating and inhibitory receptors and may mediate different functions under different circumstances. It contains cytoplasmic ITIM, suggesting inhibitory function, but also transmembrane domain similar to those of activating KIRs. It has been reported that CD158d serves as an inhibitory receptor for peripheral and uterine NK cells, but its ligation with soluble mAbs (unlike immobilized mAbs) results in activation of IFN-γ secretion. CD158d also binds both membrane form and soluble form of its ligand HLA-G.
Synonyms	KIR103AS, G9P
Reference Data

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.