TAPA1 (CD81) Mouse Monoclonal Antibody [Clone ID: M38]

Specifications

Product Data
Clone Name	M38
Applications	FC, FN, IF, IHC, IP, WB
Recommend Dilution	Flow cytometry: 1 µg/ml. Immunoprecipitation. Western blot. Immunohistochemistry on paraffin sections. Immunocytochemistry. Functional Application: In human MOLT-4 T-cell line the antibody M38 inhibits syncytium formation induced by coculture with human T-cell leukemia virus type 1 (HTLV-1)-positive human T-cell lines.
Reactivity	Feline, Human, Rabbit
Host	Mouse
Clonality	Monoclonal
Immunogen	MOLT-4 (human T-ALL cell line)
Specificity	This antibody reacts with CD81, a 25 kDa member of the tetraspanin family, expressed on majority of cells.
Formulation	Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 State: Purified State: Liquid Ig fraction
Concentration	lot specific
Purification	Protein-A affinity chromatography (> 95% by SDS-PAGE)
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C. DO NOT FREEZE!
Gene Name	CD81 molecule
Database Link	Entrez Gene 975 Human UniProt ID P60033
Background	CD81 (TAPA-1), a member of the tetraspanin family, is expressed on virtually all nucleated cells, but above all on germinal center B cells. CD81 forms complexes with other tetraspanin proteins, integrins, coreceptors, MHC class I and II molecules, and influences adhesion, morphology, activation, proliferation and differentiation of B, T and other cells – e.g. in muscles CD81 promotes cell fusion and myotube maintenance. CD81 has been also identified as a receptor for the hepatitis C virus.
Synonyms	S5.7; TAPA-1; TAPA1; Tetraspanin-28; Tspan-28; TSPAN28
Reference Data
Protein Families	Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
Protein Pathways	B cell receptor signaling pathway

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