AGR3 Mouse Monoclonal Antibody [Clone ID: AGR3.4]

Specifications

Product Data
Clone Name	AGR3.4
Applications	IF, IHC, WB
Recommend Dilution	Western blot: 1 μg/ml; Positive control: T47D breast cancer cell line; Negative control: H1299 lung carcinoma cell line. Immunocytochemistry: 1 μg/ml; Positive control: T47D breast cancer cell line; Negative control: H1299 lung carcinoma cell line. Immunohistochemistry on paraffin sections:  1 μg/ml. ositive control: T47D breast cancer cell line. Negative control: H1299 lung carcinoma cell line.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified human AGR3 protein
Specificity	This antibody recognizes the PLMII epitope of AGR3 (AG3) and AGR2 (AG2) proteins (19-20 kDa); secreted cytoplasmic proteins which can serve as markers of carcinogenesis.
Formulation	Phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent State: Aff - Purified State: Liquid Ig fraction
Concentration	lot specific
Purification	Protein-A affinity chromatography (> 95% pure by SDS-PAGE)
Conjugation	Unconjugated
Storage Condition	Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Gene Name	anterior gradient 3, protein disulphide isomerase family member
Database Link	Entrez Gene 155465 Human UniProt ID Q8TD06
Background	AGR2 (Anterior Gradient 2), also known as AG2 (hAG-2, HAG2 in human), or GOB-4, and AGR3 (Anterior Gradient 3), also known as AG3 (hAG-3, HAG3 in human), or BCMP11, are secreted cytoplasmic proteins which are involved in metastasis induction and p53 tumour supressor inhibition. They may serve as molecular markers and potential therapeutic targets for hormone-responsive breast tumours; AGR2 was reported also as a marker of other carcinomas. Xenopus homolog of these proteins is associated with anteroposterior fate determination during early development.
Synonyms	BCMP11, HAG3, HAG-3, HPC8, AG2
Reference Data

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