beta Catenin (CTNNB1) Mouse Monoclonal Antibody [Clone ID: IMD-110]

Specifications

Product Data
Clone Name	IMD-110
Applications	IF, IHC, WB
Recommend Dilution	Western Blot: 0.5 - 1 μg/ml. Immunohistochemistry on frozen sections: 1 - 2 μg/ml.
Reactivity	Chicken, Human, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant chicken beta-catenin
Specificity	This antibody reacts to Catenin beta-1.
Formulation	1.2 % sodium acetate, with 2 mg BSA and 0.01 mg sodium azide as preservative. State: Purified State: Lyphilized purified Ig fraction
Reconstitution Method	Restore with 1.2% sodium acetate or neutral PBS
Concentration	0,1 mg/ml (after reconstitution with PBS)
Purification	Affinity chromatography
Conjugation	Unconjugated
Storage Condition	Prior to reconstitution store at -20°C. Following reconstitution store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	catenin beta 1
Database Link	Entrez Gene 84353 RatEntrez Gene 1499 Human UniProt ID P35222
Background	Three catenin proteins, alpha, beta and gamma, bind to the highly conserved, intracellular cytoplasmic tail of E-cadherin. The catenin/cadherin complexes play an important role mediating cellular adhesion. Not only associated with E-cadherin, alpha-catenin was also shown to associate with other members of the cadherin family, such as N-cadherin and P-cadherin. beta-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. beta-catenin has also been found in complexes with the tumor suppressor protein APC. γ-catenin, also known as plakoglobin, is a protein that binds with alpha-catenin and N-cadherin. It has been shown that the transmembrane phosphatase PTP associates with catenin/cadherin complexes and may regulate complex signaling.
Synonyms	CTNNB1, CTNNB, Beta-catenin
Reference Data
Protein Families	Druggable Genome, ES Cell Differentiation/IPS, Transcription Factors
Protein Pathways	Adherens junction, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Basal cell carcinoma, Colorectal cancer, Endometrial cancer, Focal adhesion, Leukocyte transendothelial migration, Melanogenesis, Pathogenic Escherichia coli infection, Pathways in cancer, Prostate cancer, Thyroid cancer, Tight junction, Wnt signaling pathway

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