N Cadherin (CDH2) Mouse Monoclonal Antibody [Clone ID: NC-17]

Specifications

Product Data
Clone Name	NC-17
Applications	IHC, WB
Recommend Dilution	Western Blot: 2 μg/ml. Immunohistochemistry on frozen sections: 4 μg/ml.
Reactivity	Chicken, Human, Mouse, Rabbit, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Affinity purified chicken heart A-CAM.
Specificity	This antibody reacts to Cadherin-2.
Formulation	5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg NaN3 (all per vial) as preservative. State: Purified State: Lyphilized purified Ig fraction
Reconstitution Method	Restore with 1 ml neutral PBS to achieve stock solutiom of 0.1 mg/ml
Concentration	0.1 mg/ml (after reconstitution with PBS)
Purification	Affinity chromatography
Conjugation	Unconjugated
Storage Condition	Prior to reconstitution store at -20°C. Following reconstitution store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	cadherin 2
Database Link	Entrez Gene 12558 MouseEntrez Gene 83501 RatEntrez Gene 1000 Human UniProt ID P19022
Background	N-cadherin (NCAD) is a member of the cadherin cell-cell adhesion receptor family that includes P-, E-,and R-cadherin and liver cell adhesion molecule (L-CAM). N-Cadherin,, also known as Cadherin-2,encodes a 907-amino acid protein that includes a 159-amino acid signal sequence. Human and mouse nucleotide sequences are 96% identical. Mouse Ncad gene consists of 16 exons dispersed over more than 200 kb of genomic DNA. Human N-cadherin gene contains 16 exons and its sequence is highly similar to both the mouse NCAD gene (including the large first and second introns) and other cadherin genes. N-cadherin is mapped to 18q11.2. Cadherin regulates dendritic spine morphogenesis.
Synonyms	CDH2, CDHN, NCAD, Neural cadherin, CDw325, Cadherin N, N-Cadherin
Reference Data
Protein Families	Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
Protein Pathways	Arrhythmogenic right ventricular cardiomyopathy (ARVC), Cell adhesion molecules (CAMs)

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