EMA (MUC1) Mouse Monoclonal Antibody [Clone ID: EMA-39]

Specifications

Product Data
Clone Name	EMA-39
Applications	IF, IHC, IP
Recommend Dilution	Immunohistochemistry on Paraffin-Embedded Sections: 2-4 μg/ml, Human, By Heat. Immunohistochemistry on Frozen Sections: 2-4 μg/ml, Human.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Human milk fat globule membranes.
Specificity	This antibody reacts to CD227. No cross reactivity with other proteins.
Formulation	1.2 % sodium acetate, with 2 mg BSA and 0.01 mg sodium azide as preservative. State: Purified State: Lyphilized purified Ig fraction
Reconstitution Method	Add 1ml of PBS buffer will yield a concentration of 0.1 mg/ml.
Concentration	0,1 mg/ml (after reconstitution with PBS)
Purification	Affinity chromatography
Conjugation	Unconjugated
Storage Condition	Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing.
Gene Name	mucin 1, cell surface associated
Database Link	Entrez Gene 4582 Human UniProt ID P15941
Background	MUC1 is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages. It is expressed on most secretory epithelium, including mammary gland and some hematopoietic cells. It is expressed abundantly in lactating mammary glands and overexpressed abundantly in >90% breast carcinomas and metastases. Transgenic MUC1 has been shown to associate with all four cebB receptors and localize with erbB1 (EGFR) in lactating glands. The MUC1 gene contains seven exons and produces several different alternatively spliced variants. The major expressed form of MUC1 uses all seven exons and is a type 1 transmembrane protein with a large extracellular tandem repeat domain. The tandem repeat domain is highly Oglycosylated and alterations in glycosylation have been shown in epithelial cancer cells.
Synonyms	MUC-1, PEMT, Episialin, EMA, H23AG, PUM, DF3, CA 15-3
Reference Data
Protein Families	Druggable Genome, Secreted Protein, Transmembrane

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