gamma Catenin (JUP) Mouse Monoclonal Antibody [Clone ID: CN-3]

Specifications

Product Data
Clone Name	CN-3
Applications	IF, IHC, WB
Recommend Dilution	Western blot: Use at 0.1 - 0.5 μg/ml with the appropriate system to detect catenin Gamma (plakoglobin) in cells and tissues. Immunohistochemistry on Frozen Sections: Use at 0.5 - 1.0 μg/ml to detect Catenin Gamma (Plakoglobin) in Formalin/Acetone fixed tissues. Immunocytochemistry: Use at 1.0 μg/ml
Reactivity	Chicken, Human, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant Chicken plakoglobin.
Specificity	Recognizes Catenin Gamma (Plakoglobin). No cross reactivity with other proteins.
Formulation	1.2% Sodium Acetate containing 2mg BSA and 0.01 mg Sodium Azide as preservative. State: Aff - Purified State: Lyophilized purified IgG fraction
Reconstitution Method	Restore with 1.2% Sodium Acetate or neutral PBS.
Concentration	0.1 mg/ml (after reconstitution with 1 ml PBS).
Purification	Affinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	junction plakoglobin
Database Link	Entrez Gene 81679 RatEntrez Gene 3728 Human UniProt ID P14923
Background	Junction Plakoglobin (JUP) ,also knows as catenin gamma, is a major cytoplasmic protein that occurs in a soluble and a membrane-associated form and is the only known constituent common to the submembranous plaques of both kinds of adhering junctions, the desmosomes and the intermediate junctions. It is a component of the cadherin-catenin complex, which is predominantly localized where actin filaments anchor in adherens junctions of epithelial cells. The human plakoglobin gene localizes on chromosome 17q21. Gamma-catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of beta-catenin.
Synonyms	Desmoplakin-3, Desmoplakin III, Catenin gamma, JUP, CTNNG, DP3
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Acute myeloid leukemia, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Pathways in cancer

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