TNF alpha (TNF) Mouse Monoclonal Antibody [Clone ID: Mab1]

Specifications

Product Data
Clone Name	Mab1
Applications	ELISA, FN, WB
Recommend Dilution	Western blot. ELISA: Can be used as capture antibody in combination with biotinylated antibody MAb11. Functional application: Neutralization.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant human TNF-alpha
Specificity	This antibody recognizes human 17-26 kDa cytokine TNF-alpha (tumor necrosis factor alpha).
Formulation	PBS, pH 7.4 State: Purified State: Liquid Ig fraction Preservative: 15mM Sodium azide
Concentration	lot specific
Purification	Protein-A affinity chromatography; > 95% pure by SDS-PAGE
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C. DO NOT FREEZE!
Gene Name	tumor necrosis factor
Database Link	Entrez Gene 7124 Human UniProt ID P01375
Background	TNF-alpha is a cytokine produced by monocytes, macrophages, neutrophils, NK cells, CD4+ T cells and many transformed cells. It can be expressed as a 17 kDa free molecule, or as a 26 kDa membrane protein. TNF-alpha easily forms stable trimers, but also other multimeric complexes. In the immune system, it is an important regulator, which has cytolytic and cytostatic activity against a range of tumor cells, increases fibroblast proliferation and supports neutrophil chemotaxis and phagocytosis.
Synonyms	TNF, TNF-a, TNFA, TNFSF2, Cachectin
Reference Data
Protein Families	Druggable Genome, Secreted Protein, Transcription Factors, Transmembrane
Protein Pathways	Adipocytokine signaling pathway, Allograft rejection, Alzheimer's disease, Amyotrophic lateral sclerosis (ALS), Apoptosis, Asthma, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Fc epsilon RI signaling pathway, Graft-versus-host disease, Hematopoietic cell lineage, Hypertrophic cardiomyopathy (HCM), MAPK signaling pathway, Natural killer cell mediated cytotoxicity, NOD-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, Toll-like receptor signaling pathway, Type I diabetes mellitus, Type II diabetes mellitus

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