MCK10 (DDR1) Mouse Monoclonal Antibody [Clone ID: 2G4E12]

Specifications

Product Data
Clone Name	2G4E12
Applications	ELISA, IHC, WB
Recommend Dilution	ELISA: 1/10000. Immunohistochemistry on Paraffin Sections: 1/200 - 1/300. Western Blot: 1/500 - 1/2000.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified Recombinant fragment of DDR1 (aa 602-681) expressed in E.coli
Specificity	Recognizes Human Discoidin Domain Receptor (DDR1).
Formulation	State: Ascites State: Ascites fluid Preservative: 0.03% Sodium Azide
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	discoidin domain receptor tyrosine kinase 1
Database Link	Entrez Gene 780 Human UniProt ID Q08345
Background	DDR1 is a DDR/TKT type protein kinase. DDR1 is activated by various types of collagen, including types I through IV. Binding of collagen to DDR1 protein results in autophosphorylation and a delayed but sustained tyrosine kinase activation. DDR1 may function in cell-to-cell interaction or recognition. At least three mRNA variants, resulting in different protein isoforms of 875, 913 and 919 amino acids, have been reported. DDR1 protein has been shown to be over expressed in human breast, ovarian, esophageal and pediatric brain tumors.
Synonyms	Tyrosine kinase DDR-1, CAK, EDDR1, NEP, NTRK4, PTK3A, RTK6, TRKE, MCK10, Epithelial discoidin domain receptor 1
Reference Data
Protein Families	Druggable Genome, Protein Kinase, Transmembrane

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