Flt4 Rat Monoclonal Antibody [Clone ID: 7A3]

Specifications

Product Data
Clone Name	7A3
Applications	IF, WB
Recommend Dilution	Western Blot: 1-5 µg/ml. Immunofluorescence: 2-10 µg/ml.
Reactivity	Mouse
Host	Rat
Clonality	Monoclonal
Immunogen	Purified, insect cell-derived recombinant Mouse soluble FLT-4 (120 kDa).
Specificity	This antibody will detect Mouse VEGFR-3/FLT-4 in Western Blot in PAEC/FLT-4 cells.
Formulation	PBS pH 7.4 without preservatives State: Purified State: Lyophilized purified IgG fraction Stabilizer: None
Reconstitution Method	Restore in sterile water to a concentration of 0.1-1.0 mg/ml
Purification	Protein G Chromatography
Conjugation	Unconjugated
Storage Condition	Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing.
Gene Name	FMS-like tyrosine kinase 4
Database Link	Entrez Gene 14257 Mouse UniProt ID P35917
Background	Mature native mouse VEGF Receptor 3 (Flt4) is composed of a 751 amino acid residue extracellular domain, a 22 amino acid residue transmembrane domain, and a 565 amino acid residue cytoplasmic domain. Recombinant mature mouse VEGF Receptor 3/Fc is a disulfidelinked dimeric protein. Based on N-terminal sequencing, recombinant mouse VEGF Receptor 3/Fc has Met 17 at the amino-terminus. The amino acid sequence of mouse VEGF Receptor 3 is 88 % identical to human VEGF Receptor 3. VEGF Receptor 3 is a specific marker for lymphatic vessels. In adults, VEGF Receptor 3 expression is restricted to endothelial cells of the lymphatic vessels. It has also been detected on some high endothelial venules, in embryonic prelymphatic blood vessels, in some tumor blood vessels, and in certain hematopoietic and leukemia cells. The predominant role of VEGF Receptor 3 is its involvement in the development of the lymphatic vessel system. Both VEGFC and VEGFD bind and activate the receptors, VEGF Receptor 3 and VEGF Receptor 2.
Synonyms	VEGFR3, FLT4, VEGF Receptor 3
Reference Data

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