EGFR (Extracell. non Ligand binding Site) Mouse Monoclonal Antibody [Clone ID: EGF-R2]
CAT#: AM20237PU-N
EGFR (Extracell. non Ligand binding Site) mouse monoclonal antibody, clone EGF-R2, Purified
Need it in bulk or conjugated?
Get a free quote
CNY 4,631.00
货期*
5周
规格
Specifications
Product Data | |
Clone Name | EGF-R2 |
Applications | ELISA, FC, IHC |
Recommend Dilution | ELISA (Ref.1-3). Flow Cytometry. Immunocytochemistry (Ref.2). Immunohistochemistry on Cryosections. Immunohistochemistry on Paraffin Sections. Antigen Retrieval: Heat the deparaffinized, rehydrated sections 2x in fresh citrate buffer pH 6.0 for 5 min. in microwave. |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | Human EGF-Receptor |
Specificity | Recognizes Human EGF-Receptor (extracellular non ligand binding site). There was no cross reactivity obtained with v-erb-B |
Formulation | PBS, pH 7.4 containing 20 mM D-(+)-trehalose dihydrate, 40 mM D-(-)-mannitol State: Purified State: Lyophilized purifed IgG fraction from Cell Culture Supernatant |
Reconstitution Method | Restore in aqua bidest to 1 mg/ml |
Purification | Protein G Chromatography |
Conjugation | Unconjugated |
Storage Condition | Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing. |
Gene Name | epidermal growth factor receptor |
Database Link | |
Background | Protein kinases are enzymes that transfer a phosphate group from a phosphate donor onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. The protein kinase family is one of the largest families of proteins in eukaryotes, classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. Epidermal Growth factor receptor (EGFR) is the prototype member of the type 1 receptor tyrosine kinases. EGFR overexpression in tumors indicates poor prognosis and is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, stomach and in squamous cell carcinoma. |
Synonyms | Epidermal growth factor receptor, EGF Receptor, erbB-1, c-ErbB-1 |
Reference Data | |
Protein Families | Adult stem cells, Cancer stem cells, Druggable Genome, ES Cell Differentiation/IPS, Protein Kinase, Secreted Protein, Stem cell relevant signaling - JAK/STAT signaling pathway, Transmembrane |
Protein Pathways | Adherens junction, Bladder cancer, Calcium signaling pathway, Colorectal cancer, Cytokine-cytokine receptor interaction, Dorso-ventral axis formation, Endocytosis, Endometrial cancer, Epithelial cell signaling in Helicobacter pylori infection, ErbB signaling pathway, Focal adhesion, Gap junction, Glioma, GnRH signaling pathway, MAPK signaling pathway, Melanoma, Non-small cell lung cancer, Pancreatic cancer, Pathways in cancer, Prostate cancer, Regulation of actin cytoskeleton |
Documents
Product Manuals |
FAQs |
SDS |
Resources
抗体相关资料 |
Customer
Reviews
Loading...