PDGF Receptor alpha (PDGFRA) Mouse Monoclonal Antibody [Clone ID: 16A1]

Specifications

Product Data
Clone Name	16A1
Applications	FC
Recommend Dilution	Flow Cytometry: 10 µl reagent / 100 µl of whole blood or 10e6 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 Tests.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	CD140a-transfected NIH 3T3 cells
Specificity	This Mouse monoclonal antibody 16A1 recognizes CD140a / PDGF-RA, the 170 kDa alpha chain of platelet-derived growth factor receptor, which is widely expressed on a variety of mesenchymal-derived cells and plays pro-proliferative or anti-proliferative roles in various tumours.
Formulation	PBS Label: APC State: Liquid purified Ig fraction Stabilizer: 0.2% (w/v) high-grade BSA (Protease free) Preservative: 15 mM Sodium Azide Label: Allophycocyanin
Purification	Size-Exclusion Chromatography
Conjugation	APC
Storage Condition	Store the antibody undiluted at 2-8°C. DO NOT FREEZE! This product is photosensitive and should be protected from light.
Gene Name	platelet derived growth factor receptor alpha
Database Link	Entrez Gene 5156 Human UniProt ID P16234
Background	CD140a / PDGF-RA (platelet-derived growth factor receptor alpha) is a cell surface receptor for members of platelet-derived growth factor family, whose intracellular part contains a tyrosine kinase domain. CD140a forms homodimers, or heterodimerizes with CD140b / PDGF-RB. Whereas CD140b induces in different cell types their proliferation and migration, the role of CD140a is more controversial, with pro-proliferative or anti-proliferative effects. CD140a has early developmental functions, mediates mesodermal cell migration, and later acts in signaling associated in epithelial-mesenchymal interactions.
Synonyms	PDGF-R-alpha, PDGF Receptor alpha
Reference Data
Protein Families	Druggable Genome, ES Cell Differentiation/IPS, Protein Kinase, Transmembrane
Protein Pathways	Calcium signaling pathway, Colorectal cancer, Cytokine-cytokine receptor interaction, Endocytosis, Focal adhesion, Gap junction, Glioma, MAPK signaling pathway, Melanoma, Pathways in cancer, Prostate cancer, Regulation of actin cytoskeleton

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