CD62L (SELL) Mouse Monoclonal Antibody [Clone ID: DREG56]

Specifications

Product Data
Clone Name	DREG56
Applications	FC
Recommend Dilution	Flow cytometry analysis of human blood cells: 20 µl reagent / 100 µl of whole blood or 106 cells in a suspension. The content of a vial (2 ml) is sufficient for 100 tests.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	PMA-activated human peripheral blood leukocytes
Specificity	This antibody detects CD62L / L-selectin, a 65-76 kDa cell surface protein, expressed by neutrophils, monocytes, and subsets of T, B, and NK cells, that interacts with specific carbohydrates exposed on activated endothelial cells.
Formulation	Phosphate buffered saline (PBS) solution containing 15mM sodium azide Label: FITC State: Liquid purified Ig fraction Label: Conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC and adjusted for direct use.
Conjugation	FITC
Storage Condition	Store the antibody undiluted at 2 - 8 °C. DO NOT FREEZE! This antibody is photosensitive and should be protected from light.
Gene Name	selectin L
Database Link	Entrez Gene 6402 Human UniProt ID P14151
Background	CD62L (L-selectin) is an adhesion glycoprotein that is constitutively expressed on the cell surface of leukocytes and mediates their homing to inflammatory sites and peripheral lymph nodes by enabling rolling along the venular wall. CD62L is also involved in activation-induced neutrophil aggregation. Activation-dependent CD62L shedding, however, counteracts neutrophil rolling. CD62L has also signaling roles including enhance of chemokine receptor expression. Similarly to CD62P, the major ligand of CD62L is PSGL-1 (P-selectin glycoprotein ligand-1). The level of CD62L expression can be used to help distinguish naive T cells from effector/memory T cells.
Synonyms	SELL, LNHR, LYAM1, Leu-8, TQ1, gp90-MEL, LECAM1, LAM-1
Reference Data
Protein Families	Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
Protein Pathways	Cell adhesion molecules (CAMs)

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