CD162 (SELPLG) Mouse Monoclonal Antibody [Clone ID: TC2]

Specifications

Product Data
Clone Name	TC2
Applications	FC
Recommend Dilution	Flow Cytometry analysis of Human blood cells using 20 µl reagent / 100 ml of whole blood or 10e6 cells in a suspension. The content of a vial (2 ml) is sufficient for 100 tests.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Human thymocytes
Specificity	The antibody TC2 reacts with CD162, a 220 kDa type I integral membrane protein expressed as disulfide-linked homodimer (sialomucin family). CD162 is present on the most peripheral blood T lymphocytes, monocytes, granulocytes; it is also expressed on a subpopulation of B lymphocytes and CD34+ bone marrow cells.
Formulation	Phosphate buffered saline (PBS) containing 15 mM Sodium Azide and 0.2% (w/v) high-grade protease free BSA as a stabilizing agent Label: FITC State: Liquid purified Ig fraction Label: Fluorescein isothiocyanate ; free of unconjugated
Conjugation	FITC
Storage Condition	Store the antibody at 2-8 °C. DO NOT FREEZE! This product is photosensitive and should be protected from light.
Gene Name	selectin P ligand
Database Link	Entrez Gene 6404 Human UniProt ID Q14242
Background	CD162 (P-selectin glycoprotein ligand-1, PSGL-1) is a sialomucin constitutively expressed as a disulfide-linked homodimer of two 120 kDa subunits on the surface of circulating leukocytes. CD162 serves as a ligand for P- E- and L-selectin, with the highest affinity for P-selectin. It is thus involved in leukocyte rolling at the endothelial surfaces, prerequisite for firm leukocyte adhesion and subsequent transendothelial migration. CD162 also mediates leukocyte-platelet adhesion and interleukocyte contacts. Whereas serving as an adhession molecule on mature leukocytes, CD162 is a potent negative regulator of human hematopoietic progenitors.
Synonyms	PSGL-1, Selectin P ligand, SELPLG
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Cell adhesion molecules (CAMs)

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