ALIX (PDCD6IP) Mouse Monoclonal Antibody [Clone ID: 8E8]

Specifications

Product Data
Clone Name	8E8
Applications	ELISA, IHC, WB
Recommend Dilution	ELISA. Western Blot: 1/200-1/1000. Immunohistochemistry: 1/100-1/500.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified recombinant Human ALIX protein
Specificity	Reacts with Human 96 kDa ALIX protein.
Formulation	0.1M Tris, 0.1M Glycine and 2% Sucrose State: Purified State: Lyophilized purified powder Preservative: None
Reconstitution Method	Restore in distilled water.
Concentration	lot specific
Purification	Protein A Chromatography
Conjugation	Unconjugated
Storage Condition	Lyophilized powder stable for a minimum of 2 years at -20°C. Store reconstituted antibody at 2-8°C (in aliquots) at -20°C for longer.
Gene Name	programmed cell death 6 interacting protein
Database Link	Entrez Gene 10015 Human UniProt ID Q8WUM4
Background	ALIX was originally reported to play a role in apoptosis but has recently been shown to be involved in other cellular mechanisms including endosomal sorting, endocytosis, viral budding and actin cytoskeleton assembly.ALG2 interacting protein X is a Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles. Fusion between endosomes and the vacuole will then target the cargo proteins to the vacuolar lumen. In case of infection, the HIV-1 virus directly takes advantage of its function for viral exocytosis and budding, via its interaction with HIV-1 p6 protein. It may play a role in the regulation of both apoptosis and cell proliferation
Synonyms	PDCD6-interacting protein, ALG-2-interacting protein 1, Hp95, KIAA1375
Reference Data

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