Ubiquitin (UBB) Mouse Monoclonal Antibody [Clone ID: 10C2-2]

Specifications

Product Data
Clone Name	10C2-2
Applications	ELISA, IHC, WB
Recommend Dilution	ELISA: 1/10-1/100. Western Blot: 1/10-1/100. Immunohistochemistry: 1/10-1/100.
Host	Mouse
Clonality	Monoclonal
Immunogen	Ubiquitin
Specificity	The antibody reacts specifically with 8.5kDa protein and ubiquitinilated proteins.
Formulation	State: Supernatant State: Lyophilized powder from Cell Culture Supernatant Preservative: None
Reconstitution Method	Restore in distilled water.
Conjugation	Unconjugated
Storage Condition	Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing.
Gene Name	ubiquitin B
Database Link	UniProt ID P0CG47
Background	Ubiquitin is a highly conserved protein of about 8.5 kDa molecular weight, which has an ATP dependent role in the targeting of proteins for proteolytic degradation. To perform this function, the protein to be degraded is first covalently attached to the C terminus of ubiquitin, and the ubiquitinated complex is then recognized by a complex of degradative enzymes. Interestingly, ubiquitin also becomes covalently bonded to many types of pathological inclusions, which appear to be resistant to normal degradation. Therefore, ubiquitin antibodies are very useful for studies of these inclusions. For example, the neurofibrillary tangles and paired helical filaments diagnostic of Alzheimer's disease, Lewy bodies seen in Parkinson's disease, and Pick bodies found in Pick's disease are all heavily ubiquitinated and can be readily visualized with ubiquitin antibodies.
Synonyms	UBB, Polyubiquitin-B
Reference Data

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