SNF5 (SMARCB1) Mouse Monoclonal Antibody [Clone ID: 25]

Specifications

Product Data
Clone Name	25
Applications	IHC
Recommend Dilution	Immunohistochemistry on Formalin-Fixed, Paraffin-Embedded Sections: 1/50-1/100 Pretreatment of deperaffinized tissue with heat-induced epitope retrieval is recommended. Use Polymer anti Mouse/Rabbit IgG as a detection system. Positive Control: Brain or astrocytoma.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Mouse BAF47 amino acids 257-359
Specificity	Lack of nuclear labeling by anti-INI-1 is characteristic of MRT. The majority of medulloblastomas and sPNETs are labeled by anti-INI-1 antibody. MRTs also originate from the kidney and soft tissues. Cellular Localization: Nuclear.
Formulation	State: Supernatant State: Liquid Tissue Culture Supernatant with 0.2% BSA and 15mM Sodium Azide.
Concentration	N/A
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C.
Gene Name	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
Database Link	Entrez Gene 3623 HumanEntrez Gene 6598 Human UniProt ID Q12824
Background	The INI-1 gene, which encodes a functionally uncharacterized protein component of the hSWI/SNF chromatin remodeling complex, is often mutated or deleted in malignant rhabdoid tumor (MRT). Two isoforms of INI-1, that differ by the variable inclusion of amino acids, potentially are produced by differential RNA splicing. The morphology of MRTs can present challenges in differential diagnosis. The overall survival of MRTs relative to its potential mimics (medulloblastoma, supratenorial primitive neuroectodermal tumors (sPNETs)) is quite low, and thus differentiation from these other tumors is desirable.
Synonyms	Integrase interactor 1 protein, INI1, SNF5 homolog, SNF5L1, BAF47
Reference Data
Protein Families	Druggable Genome, Secreted Protein

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