CD31 (PECAM1) Mouse Monoclonal Antibody [Clone ID: JC70A]

Specifications

Product Data
Clone Name	JC70A
Applications	IHC
Recommend Dilution	Immunohistochemistry on Formalin-Fixed, Paraffin-Embedded Sections: 1/50-1/100 Pretreatment of deperaffinized tissue with heat-induced epitope retrieval is recommended. Use Polymer anti Mouse/Rabbit IgG as a detection system. Positive Control: Placenta.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Preparation of a spleen from a patient with hairy cell leukemia.
Specificity	This antibody Recognizes CD31/PECAM1. JC/70A reacts with endothelial cells in normal tissues and in benign and malignant proliferations. In Cryostat Sections and blood smears the antibody also stains megakaryocytes, platelets and occasionally plasma cells.1 It reacts weakly with mantle zone B cells, peripheral T cells, and neutrophils. Cellular Localization: Cell membrane.
Formulation	State: Supernatant State: Liquid Tissue Culture Supernatant with 0.2% BSA and 15mM Sodium Azide.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C.
Gene Name	platelet and endothelial cell adhesion molecule 1
Database Link	Entrez Gene 9332 HumanEntrez Gene 5175 Human UniProt ID P16284
Background	CD31, also known as platelet endothelial cell adhesion molecule 1 (PECAM1), is a type I integral membrane glycoprotein and a member of the immunoglobulin superfamily of cell surface receptors. It is constitutively expressed on the surface of endothelial cells, and concentrated at the junction between them. It is also weakly expressed on many peripheral lymphoid cells and platelets. CD31 has been used to measure angiogenesis in association with tumor recurrence. Other studies have also indicated that CD31 and CD34 can be used as markers for myeloid progenitor cells and recognize different subsets of myeloid leukemia infiltrates (granular sarcomas). CD31 is expressed in platelets, cultured endothelial cells, monocytes, normal tissue macrophages in tonsil, lung and kidney as well as in skin biopsies from conditions such as sarcoidosis and lepromatous leprosy.
Synonyms	PECAM-1, EndoCAM, GPIIA'
Reference Data
Protein Families	Druggable Genome, Secreted Protein, Transmembrane

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