Thyroglobulin (TG) Mouse Monoclonal Antibody [Clone ID: TG221]

Specifications

Product Data
Clone Name	TG221
Applications	FC, IF, IHC
Recommend Dilution	Suitable for Immunohistochemistry and Immunocytochemistry (Frozen or Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections and cell smears) For IHC dilute concentared antibody at 1/50-1/200, use streptavidin~biotin system or polymer system, incubate 30 minutes at room temperature. Immunofluorescence: 10-20 µg/ml (1/10-1/20), incubate for 2 hours in the dark at RT or it can also be incubated overnight at 4ºC. Flow Cytometry: 0.2-1.0 µg/0.1 ml (1/200-1/1,000). Recommended Positive Control: Human thyroid.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified human Thyroglobulin.
Specificity	This antibody Tg is useful in identification of thyroid carcinoma of the papillary and follicular types. Presence of Tg in metastatic lesion establishes thyroid origin of tumor. Cellular Localization: Cytoplasmic.
Formulation	PBS, pH 7.4 containing 1% BSA as stabilizer and 0.05% Sodium Azide as preservative. Label: FITC State: Liquid purified Ig fraction.
Concentration	lot specific
Conjugation	FITC
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. This product is photosensitive and should be protected from light.
Gene Name	thyroglobulin
Database Link	Entrez Gene 7038 Human UniProt ID P01266
Background	Thyroglobulin (Tg) is a 660 kDa dimeric protein produced by and used by entirely within thyroid gland. Tg is used by the thyroid gland to produce the thyroid hormone thyroxine (T4) and triiodothyronine (T3). Tg is produced by the thyroid epithelial cells, called thyrocytes, which form spherical follicles. Tg is stored in the follicle lumen. Tg levels in the blood can be used as markers for certain kind of thyroid cancer. Tg levels are also elevated in Graves disease.
Synonyms	Thyreoglobulin, TGN
Reference Data

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