ADK (22-362) Mouse Monoclonal Antibody [Clone ID: AT4F8]

Specifications

Product Data
Clone Name	AT4F8
Applications	ELISA, FC, IF, WB
Recommend Dilution	ELISA. Western blot (1:1000). Immunocytochemistry / Immunoflourescence. Flow cytometry.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant human ADK (22-362aa) purified from E. coli
Specificity	The antibody recognizes human Adenosine kinase at aa 22-362. Other species not tested.
Formulation	PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Protein-G affinity chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	adenosine kinase
Database Link	Entrez Gene 132 Human UniProt ID P55263
Background	Adenosine kinase (ADK) is the key regulator of adenosine metabolism. Because of the manifold receptor-dependent actions of adenosine, tight regulation of adenosine levels is crucial. The intracellular and extracellular pools of adenosine are in dynamic exchange by equilibrative and concentrative nucleoside transporters, so extracellular concentrations of adenosine are regulated by interplay of theses transporters with intracellular and extracellular enzymes of adenosine metabolism. Thus, the extracellular concentration of adenosine is enhanced by inhibition of equilibrative nucleoside transporters such as S-(4-nitrobenzyl)-6-thioinosine and cannabidiol and, stimulation of extracellular ATP breakdown and inhibition of intracellular adenosine removal.
Synonyms	ADK, AK
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Metabolic pathways, Purine metabolism

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