LDHA Mouse Monoclonal Antibody [Clone ID: AT1A4]

Specifications

Product Data
Clone Name	AT1A4
Applications	ELISA, IF, WB
Recommend Dilution	ELISA. Western blot (1/500-1/8000). Immunofluorescence (1/500-1/8000).
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant Human LDHA (1-332aa) purified from E. coli
Specificity	The antibody recognizes Human LDHA. Other species not tested.
Formulation	PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Affinity chromatography on Protein G
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	lactate dehydrogenase A
Database Link	Entrez Gene 3939 Human UniProt ID P00338
Background	Lactate through lactate dehydrogenase A (LDHA), which is encoded by a target gene of c-Myc and hypoxia-inducible factor (HIF-1). LDHA expression is repressed by SugR in the absence of sugar. Reduction of LDHA causes bioenergetic and oxidative stress leading to cell death. LDHA (LDH-5, M-LDH, or A4), which is the predominant form in skeletal muscle, kinetically favors the conversion of pyruvate to lactate. Therefore, LDH-A is an attractive target for cancer therapy since its expression is largely relegated to skeletal muscle.
Synonyms	LDH-A, L-lactate dehydrogenase A chain, LDH-M, PIG19, NY-REN-59
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Cysteine and methionine metabolism, Glycolysis / Gluconeogenesis, Metabolic pathways, Propanoate metabolism, Pyruvate metabolism

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