CLEC4E Mouse Monoclonal Antibody [Clone ID: AT16E3]

Specifications

Product Data
Clone Name	AT16E3
Applications	ELISA, IF, IHC, WB
Recommend Dilution	ELISA. Western blot: 1/250-1/1000. Immunofluorescence: 1/250-1/500. Immunohistochemistry on Paraffin Embedded tissues: 1/50.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant Human MINCLE (41-219aa) purified from E. coli
Specificity	The antibody recognizes Human CLEC4E (MINCLE). Other species not tested.
Formulation	PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Protein-G Affinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	C-type lectin domain family 4 member E
Database Link	Entrez Gene 26253 Human UniProt ID Q9ULY5
Background	MINCLE (macrophage inducible C-type lectin, also called CLEC4E or CLECSF9), which is a diverse family of protein which was originally defined by their ability to recognize a wide range of ligand of carbohydrate structure. MINCLE expressed in macrophages subjected to several types of stress. It plays an essential role in response to trehalose-6,6'-dimycolate (TDM) and activated by a synthetic analogue, trehalose dibehenate (TDB). Recently it was reported that MINCLE is associated with an immunoreceptor tyrosine-based activation motif–containing Fc receptor γ chain (FcRγ) and functions as an activating receptor for damaged self- and non–self-pathogenic fungi.
Synonyms	CLECSF9, MINCLE
Reference Data
Protein Families	Druggable Genome, Transmembrane

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