STAT5B pTyr694 Mouse Monoclonal Antibody [Clone ID: A2H6]

Specifications

Product Data
Clone Name	A2H6
Applications	ELISA
Recommend Dilution	Indirect ELISA: the antibody is reactive to Tyrosine699 phosphorlylated Human STAT5b peptide fragment conjugated with KLH or the peptide-BSA conjugate. The suggested antigen coating quantity is 1 ug/ml of peptide/or peptide conjugating in pH 9.5 carbonate buffer, 100 ul/well.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	A Tyrosine 699 phosphorylated Human STAT5b peptide fragment conjugated with KLH.
Specificity	Reactive to Tyrosine 699 phosphorlylated human STAT5b peptide fragment conjugated with KLH or the peptide-BSA conjugate, but not reactive to unconjugated KLH or BSA.
Formulation	0.01M PBS, pH 7.2 without preservatives State: Aff - Purified State: Lyophilized purified IgG fraction
Reconstitution Method	Restore with Double distillated water to adjust the final concentration to 1.0 mg/ml.
Purification	Affinity chromatography on Protein G
Conjugation	Unconjugated
Storage Condition	Upon receipt, store (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Gene Name	signal transducer and activator of transcription 5B
Database Link	Entrez Gene 6777 Human UniProt ID P51692
Background	Stat5b is a transcription factor that is activated in response to extra-cellular stimuli including IL-2, IL-4, MCSF and a variety of growth factors. In the process, receptor associated kinases phosphorylate Stat5b. Stat5b, then, forms dimers and translocates to nucleus. Inside nucleus, Stat5b binds to the promoter region on various genes to regulate biological processes such as apoptosis, T cell receptor signalling, and adult mammary gland development. Fusion of Stat5b to retinoic acid receptor-alpha (RARα) gene was identified in a small subgroup of acute promyelocytic leukemia patients.
Synonyms	STAT-5B
Reference Data
Protein Families	Druggable Genome, ES Cell Differentiation/IPS, Stem cell relevant signaling - JAK/STAT signaling pathway, Transcription Factors
Protein Pathways	Acute myeloid leukemia, Chemokine signaling pathway, Chronic myeloid leukemia, ErbB signaling pathway, Jak-STAT signaling pathway, Pathways in cancer

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