CREB1 pSer133 Mouse Monoclonal Antibody [Clone ID: A3A4]

Specifications

Product Data
Clone Name	A3A4
Applications	ELISA
Recommend Dilution	Indirect ELISA: The antibody is reactive to serine133 phosphorylated Human CREB peptide and reactive to Serine133 phosphorylated human CREB peptide conjugated with KLH or BSA. The suggested antigen coating quantity is 1 µg/ml of peptide/or peptide conjugating in pH 9.5 carbonate buffer, 100 µl/well.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Peptide of a phosphorylated fragment of CREB [pSer133], conjugated with KLH
Specificity	Reactive to Serine133 phosphorylated Human CREB peptide fragment, and reactive to KLH or BSA conjugated Serine133 phosphorylated Human CREB peptide fragment.
Formulation	0.01 M PBS, pH 7.0 without preservatives State: Aff - Purified State: Lyophilized purified IgG fraction.
Reconstitution Method	Restore with Double distillated water to adjust the final concentration to 1.0 mg/ml.
Purification	Affinity Chromatography on Protein G
Conjugation	Unconjugated
Storage Condition	Upon receipt, store (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Gene Name	cAMP responsive element binding protein 1
Database Link	Entrez Gene 1385 Human UniProt ID P16220
Background	Transcription factor CREB binds the cAMP response element (CRE) and activates transcription in response to a variety of extracellular signals including neurotransmitters, hormones, membrane depolarization, and growth or neurotrophic factors. Protein kinase A and the calmodulin-dependent protein kinase CaMKII stimulate CREB phosphorylation at Ser133, a key regulatory site controlling transcriptional activity. Phosphorylation at Ser133 is also mediated by p44/42 MAP kinase, p90RSK, p38 MAP kinase and MSK1. CREB appears to play an important role in learning and memory in both flies and mice.
Synonyms	CREB-1
Reference Data
Protein Families	Druggable Genome, Transcription Factors
Protein Pathways	Antigen processing and presentation, Huntington's disease, Melanogenesis, Prostate cancer

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