Plakophilin 4 (PKP4) (85-104) Mouse Monoclonal Antibody [Clone ID: 7.7.9 (p0071-1)]

Specifications

Product Data
Clone Name	7.7.9 (p0071-1)
Applications	IF, IHC, WB
Recommend Dilution	Immunoblotting: 1/10-1/50. Immunofluorescence: Undiluted. Immunohistochemistry on Frozen Sections: Undiluted. Immunohistochemistry on Paraffin Sections: Incubation Time: 1-1.5 h at RT. Positive Control: MCF-7 cells.
Reactivity	Bovine, Human, Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	Synthetic peptide of human p0071 (aa position 85-104: EKSFPWRSTDVNTGVSKPR)
Specificity	This antibody recognizes Plakophilin-4. Detects a plaque protein (p0071) specific for a subtype of adherens junctions, with a molecular mass of 135 kD and is closely related to neurojungin / delta-catenin and ARVC (all belonging to the p120 armadillo subfamily). p0071 is specifically detected in the plaques of the composite junctions (area compositae) of cardiac intercalated disks, in puncta adhaerentia of single- and multi-layered epithelia and blood vessel endothelial cells.; it is, however, absent from desmosomes. This protein was also described as plakophilin 4. Tested Reactivities on Cultured Cell Lines:MCF-7, A431, CaCo-2, HT-29, PLC, 16HBE14o, HaCaT, SV80, U333 CG, 3T3, RVF-SMC, MH1C1.
Formulation	State: Supernatant State: Liquid Hybridoma Culture Supernatant Preservative: 0.09% Sodium Azide
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	plakophilin 4
Database Link	Entrez Gene 8502 Human UniProt ID Q99569
Background	Plakophilin 4 (PKP4) is an Armadillo-like protein, characterized by a series of armadillo repeats. It is a component of desmosomal plaques and may play a role in junctional plaque organization.
Synonyms	PKP4, p0071
Reference Data

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