Apolipoprotein E (APOE) Mouse Monoclonal Antibody [Clone ID: E3]

Specifications

Product Data
Clone Name	E3
Applications	ELISA, WB
Recommend Dilution	ELISA. Western Blot: 1/200 with PBS, pH 7.4 for Immunoblotting (ECL).
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Human Apolipoprotein E
Specificity	This antibody reacts with all isoforms E2, E3, E4 of Human Apolipoprotein E (ApoE). Detects a 38 kDa band in Western Blotting.
Formulation	PBS, pH 7.4 State: Aff - Purified State: Lyophilized purified IgG fraction Stabilizer: 0.5% BSA Preservative: 0.09% Sodium Azide
Reconstitution Method	Restore in 1 ml distilled water
Purification	Affinity Chromatography on Protein G
Conjugation	Unconjugated
Storage Condition	Prior to reconstitution store at 2-8°C. Following reconstitution store the antibody at -20°C. Avoid repeated freezing and thawing.
Gene Name	apolipoprotein E
Database Link	Entrez Gene 348 Human UniProt ID P02649
Background	Apolipoprotein E is essential for the normal catabolism of triglyceride rich lipoprotein constituents. The apolipoprotein E gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in Apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. Mutations in the APOE gene confer susceptibility to Alzheimer's disease by affecting amyloid-beta deposition.
Synonyms	ApoE, Apo-E
Reference Data
Protein Families	Adult stem cells, Druggable Genome, Secreted Protein, Stem cell - Pluripotency
Protein Pathways	Alzheimer's disease

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