HMG1 (HMGB1) Mouse Monoclonal Antibody [Clone ID: J2E1]

Specifications

Product Data
Clone Name	J2E1
Applications	ELISA, IHC, WB
Recommend Dilution	ELISA. Western blot (1:500 - 1:2,000), recommended starting dilution is 1:1,000. Immunohistochemistry (1:100 - 1:300), recommended starting dilution is 1:200.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant human HMGB1 (1-215aa) purified from High Five (Trichoplusia ni) insect cells.
Specificity	The antibody recognizes human HMGB1. Other species not tested.
Formulation	PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Protein-G affinity chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	high mobility group box 1
Database Link	Entrez Gene 3146 Human UniProt ID P09429
Background	High mobility group box1 protein (HMGB1) is a very abundant chromatin-binding protein residing in the eukaryotic cell nucleus and acting in the assembly of nucleoprotein complexes. Inside the cell, HMGB1 binds to DNA and has a role in transcriptional regulation. Outside the cell, HMGB1 acts as a cytokine and has activities that resemble those of tumor necrosis factor.
Synonyms	High mobility group protein 1, HMG1, HMG-1, High mobility group protein B1, HMGB-1, Amphoterin
Reference Data
Protein Families	Druggable Genome, Stem cell - Pluripotency, Transcription Factors
Protein Pathways	Base excision repair

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