FADD Mouse Monoclonal Antibody [Clone ID: 1A11]

Specifications

Product Data
Clone Name	1A11
Applications	ELISA, IP, WB
Recommend Dilution	ELISA. Immunoprecipitation. Western Blot.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Specificity	This antibody is specific for FADD.
Formulation	2 ml of 100 mM Borate buffered saline, pH 8.2. No preservatives or amine-containing buffer salts added Label: Sepharose State: Liquid purified Ig fraction. Label: 4B (SEPH)
Conjugation	Sepharose
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Store protected from light. Avoid repeated freezing and thawing.
Gene Name	Fas associated via death domain
Database Link	Entrez Gene 8772 Human UniProt ID Q13158
Background	Fas-associated death domain (FADD, also known as MORT1) is an important apoptosis adapter molecule involved in the Fas-mediated cell death pathway. FADD associates with the intracellular domain of FAS (CD95/APO-1) through their respective C-terminal death domains (DD). The N-terminal region of FADD contains a death effectors domain (DED) which recruits and binds cytosolic proteins such as FLICE/caspase-8. The subsequent activation of FLICE by proteolytic cleavage leads to the activation of the caspase-mediated (ICE-related proteases) apoptotic cascade. Overexpression of FADD induces apoptosis which is inhibited by CrmA, a specific inhibitor of the interleukin-1a-converting enzyme. FADD has also been shown under certain circumstances to promote cell survival and proliferation. (Ref.1-6)
Synonyms	FAS-associated death domain protein, MORT1, GIG3
Note	Shake well before use.
Reference Data

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