Cytokeratin 19 (KRT19) (C-term) Mouse Monoclonal Antibody [Clone ID: SB39g]

Specifications

Product Data
Clone Name	SB39g
Applications	ELISA, IF, IHC, WB
Recommend Dilution	ELISA. Western Blot: 1/2,000-1/4,000. Immunohistochemistry (Acetone-Fixed, Frozen Tissue Sections): 10 µg/ml
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant C-terminal keratin 19.
Specificity	This antibody reacts specifically specifically with cytokeratin 19 and recombinant C-terminal keratin 19. Monoclonal antibodies to cytokeratin proteins can be useful markers for tumor identification and classification. The degree of cytokeratin 19 positivity in breast cancer distinguishes malignant from benign tumors. Cytokeratin 19 is also associated with malignant transformation in esophageal and pancreatic cancers. (Ref.8,9)
Formulation	100 mM Borate buffered saline, pH 8.0 without preservatives or amine-containing buffer salts. State: Purified State: Liquid purified Ig fraction.
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C.
Gene Name	keratin 19
Database Link	Entrez Gene 3880 Human UniProt ID P08727
Background	Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1-8). The two keratin types share only 30% sequence homology. (Ref.1-5) Keratins demonstrate tissue- and differentiation-specific expression profiles. Cytokeratin 19 is the smallest human keratin, is found in many simple and some non-keratinizing stratified squamous epithelia, and is often co-expressed with keratin 7.(Ref.6,7) Cytokeratin 19 has been implicated as a marker for stem cells in some tissues, such as hair follicles in the skin.
Synonyms	Cytokeratin-19, Keratin-19, KRT19, CK19, K19
Note	Chatacterization: To ensure acceptable performance, each batch of product is tested by ELISA, Immunohistochemical staining (HT29 and HCC38 cells) and Western blotting (HT29 and HCC38 cell lysates) to conform to characteristics of a standard reference reagent.
Reference Data

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.