LAMP1 Mouse Monoclonal Antibody [Clone ID: H4A3]

Specifications

Product Data
Clone Name	H4A3
Applications	FC, IHC, WB
Recommend Dilution	Western Blot: 2 µg/ml. Flow Cytometry: ≤ 1 µg/106 cells. Immunohistochemistry (Acetone-Fixed, Frozen Tissue Sections).
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Specificity	This antibody recognizes Human CD107a/LAMP-1. Other species not tested.
Formulation	100 mM Borate Buffered Saline, pH 8.2 without preservatives. State: Purified State: Liquid purified Ig fraction.
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	lysosomal associated membrane protein 1
Database Link	Entrez Gene 3916 Human UniProt ID P11279
Background	CD107a, also known as lysosomal-associated membrane protein 1 (LAMP-1), is a heavily glycosylated, type I transmembrane protein that constitutes the major sialoglycoproteins on lysosomal membranes. It is a ligand for galaptin, an S-type lectin present in extracellular matrix, through its recognition of acetyllactosamine oligosaccharide chains, and is a ligand for E-selectin-mediated cell adhesion. CD107a is expressed by granulocytes, T cells, macrophages, dendritic cells, activated platelets, tonsillar epithelium and some tumor cell lines, including U937 and KG1a. It is also a widely expressed intracellular antigen. LAMP-1 may function in protecting the inner surface of the lysosomal membrane by forming a barrier to lysosomal hydrolases. The upregulation of both CD107a and CD107b on the surface of tumor cell lines has been associated with their enhanced metastatic potential, where they may increase adhesion to extracellular matrix and endothelium. (Ref.1-7)
Synonyms	LAMP-1, LAMPA, LGP120
Reference Data

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