MHC Class II Mouse Monoclonal Antibody [Clone ID: 2G11]

Specifications

Product Data
Clone Name	2G11
Applications	FC, IHC, IP, WB
Recommend Dilution	Flow Cytometry: ≤ 1 µg/106 cells. (Ref.2-6) Immunoprecipitation (Ref.7). Immunohistochemistry(Ref.6). Immunoblotting (Ref.6).
Reactivity	Chicken
Host	Mouse
Clonality	Monoclonal
Specificity	This antibody recognizes Chicken MHC Class II (B-L) molecules. Mr. 30-42 kDa.
Formulation	100 mM Borate Buffered Saline, pH 8.2. No preservatives or amine-containing buffer salts added. State: Purified State: Liquid purified Ig fraction.
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Background	MHC Class II antigens are heterodimers consisting of one alpha chain(31-34kD) and one beta chain (26-29kD). The family of monoclonal antibodies (ER-TR 3, ER-TR 2, ER-TR 1) detect MHC class II antigens encoded by the murine Ia region of the H-2 complex, corresponding to the human HLA-DR region. MHC Class II antigens are a valuable tool for studying T helper cell interaction with class II positive antigen presenting cells (dendritic cells, B cells, macrophages) and offer new possibilities for studying the development of T helper cells since these antibodies also stain stromal cells in the thymus. MHC Class II antigens are also inducible on a number of other cells (endothelium and epithelial cells) by interferon gamma.
Synonyms	MHC Class 2, HLA Class II
Reference Data

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