Lamp1 Rat Monoclonal Antibody [Clone ID: 1D4B]

Specifications

Product Data
Clone Name	1D4B
Applications	FC
Recommend Dilution	Flow Cytometry: < / = 1 µg/10e6 cells. (Ref.5)
Reactivity	Mouse
Host	Rat
Clonality	Monoclonal
Immunogen	Plasma membrane fraction of mouse embryo NIH3T3 cell line. (Ref.1)
Specificity	This antibody is specific to CD107a/LAMP-1 (Mr 110-140 kDa with a core protein of Mr ~40 kDa).
Formulation	PBS containing 0.09% Sodium Azide as preservative. Label: FITC State: Liquid purified Ig fraction. Label: Fluorescein Isothiocyanate Isomer 1
Concentration	lot specific
Conjugation	FITC
Storage Condition	Store the antibody undiluted at 2-8°C for one month or in (aliquots) at -20°C for longer. This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing.
Gene Name	lysosomal-associated membrane protein 1
Database Link	Entrez Gene 16783 Mouse UniProt ID P11438
Background	CD107a, also known as lysosomal-associated membrane protein 1 (LAMP-1), is a heavily glycosylated, type I transmembrane protein that constitutes one of the two major sialoglycoproteins on lysosomal membranes that can be used to distinguish lysosomes from other organelles. (Ref.1) It is a ligand for galaptin, an S-type lectin present in extracellular matrix, through its recognition of acetyllactosamine oligosaccharide chains, and is a ligand for E-selectin-mediated cell adhesion. (Ref.2) CD107a is principally expressed in epithelial cells and macrophages in a variety of organs in normal and Beige mutant mice. (Ref.3) LAMP-1 may function in protecting the inner surface of the lysosomal membrane by forming a barrier to lysosomal hydrolases. (Ref.4)
Synonyms	LAMP-1, LAMPA, LGP120
Reference Data

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