Itgb7 Rat Monoclonal Antibody [Clone ID: DATK32]

Specifications

Product Data
Clone Name	DATK32
Applications	FC, FN, IHC
Recommend Dilution	Flow Cytometry: ≤ 1 µg/106 cells. (Ref.1-4) Immunohistochemistry on Frozen Sections. (Ref.3) Induction of homotypic cellular aggregation. (Ref.1) Blockade of binding to cell adhesion molecules. (Ref.1)
Reactivity	Mouse
Host	Rat
Clonality	Monoclonal
Immunogen	AKR/Cum mouse spontaneous T lymphoma cell line TK1. (Ref.1)
Specificity	This antibody is specific to mouse LPAM1 (Integrin alpha 4 beta 7). It recognises a conformational epitope on the heterodimer.
Formulation	100 mM Borate Buffered Saline, pH 8.2. No preservatives or amine-containing buffer salts added. State: Purified State: Liquid purified Ig fraction.
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	integrin beta 7
Database Link	Entrez Gene 16421 Mouse UniProt ID P26011
Background	The lymphocyte Peyer’s patch adhesion molecule (LPAM-1), also known as Integrin alpha 4 beta 7 is a member of the integrin family of cell surface receptors. It is expressed primarily on mucosal lymphocytes, but is also present on NK cells and eosinophils. The alpha 4 beta 7 heterodimer mediates the binding of lymphocytes to its ligand, mucosal vascular addressin (MAdCAM1) on the high endothelial venules, thereby directing the homing of lymphocytes into Peyer's patches and intestinal lamina propria. (Ref.1-4)
Synonyms	Integrin beta-P, M290 IEL antigen, ITGB7, LPAM-1, LPAM1
Reference Data

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