CD81 / TAPA1 Hamster Monoclonal Antibody [Clone ID: 2F7]

Specifications

Product Data
Clone Name	2F7
Applications	FC, FN, IHC, IP
Recommend Dilution	Flow Cytometry: Identification and enumeration of CD81+ cells. Immunoprecipitation. Immunohistochemistry on Frozen Sections. In vitro blocking of thymocyte interactions with CD81. See Ref.2 for more details.
Reactivity	Mouse
Host	Hamster
Clonality	Monoclonal
Immunogen	Mouse epithelial cell line PAM212.
Specificity	This antibody recognises Mouse CD81 (Mr 25 kDa), a member of the transmembrane 4 integral membrane protein family. This antibody can block thymocyte interaction with CD81 in vitro. (Ref.2)
Formulation	100 mM Borate Buffered Saline, pH 8.2. No preservatives or amine-containing buffer salts added. State: Purified State: Liquid purified Ig fraction.
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	CD81 antigen
Database Link	Entrez Gene 12520 Mouse UniProt ID P35762
Background	TAPA1, or CD81, is a member of the transmembrane 4 superfamily, also known as the Tetraspanin family. Most of these members are cell surface proteins that are characterised by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. TAPA1 is a cell surface glycoprotein that is known to complex with integrins. It appears to promote muscle cell fusion and support myotube maintenance. Also it may be involved in signal transduction. TAPA1 gene is localized in the tumor suppressor gene region and thus it is a candidate gene for malignancies.
Synonyms	S5.7; TAPA-1; TAPA1; Tetraspanin-28; Tspan-28; TSPAN28
Reference Data

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