T Cell Receptor (TCR) gamma/delta Hamster Monoclonal Antibody [Clone ID: UC7-13D5]
CAT#: AM08059LE-N
T Cell Receptor (TCR) gamma/delta hamster monoclonal antibody, clone UC7-13D5, Low Endotoxin
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CNY 5,379.00
货期*
4周
规格
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Specifications
Product Data | |
Clone Name | UC7-13D5 |
Applications | FC |
Recommend Dilution | Flow Cytometry. This clone as has also been described to work in Immunoprecipitation, In vitro Activation of gamma-delta TCR-bearing cells and In vivo Depletion of gamma-delta TCR-expressing T cells. (Bluestone, J.A., et al. 1991. Immunol. Rev. 120:5). |
Reactivity | Mouse |
Host | Hamster |
Clonality | Monoclonal |
Specificity | This Monoclonal antibody is specific to the gamma-delta heterodimer and plate-bound UC7-13D5 activates gamma-delta TCR-bearing cells. It does not react with alpha-beta TCR-expressing T cells. (Davis, M.M. 1990. Annu. Rev. Biochem. 59:475. Allison, J.P., and W.L. Havran. 1991. Annu. Rev. Immunol. 9:679. Klausner, R.D., and L.E. Samuelson. 1991. Cell 64:875. Dent, A.L., et al. 1990. Nature 343:714.) |
Formulation | PBS containing no preservatives. State: Low Endotoxin State: Liquid purified Ig fraction. |
Concentration | lot specific |
Conjugation | Unconjugated |
Storage Condition | Store the antibody undiluted (in aliquous) at -20°C. Avoid repeated freezing and thawing. |
Background | T cell receptors (TCR) recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. This region represents the germline organization of the T cell receptor beta locus. The beta locus includes V (variable), J (joining), diversity (D), and C (constant) segments. During T cell development, the beta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The C segment is later joined by splicing at the RNA level. The TCR gamma/delta heterodimer of the CD3/T-cell receptor complex is clonotypic and consists of Ig-like variable and constant domains. (Ref.1) It is expressed during thymopoiesis and on the small subpopulation of gamma/delta TCR expressing T lymphocytes in the periphery. The majority of T cells present in some epithelial tissues are gamma/delta+ and have limited receptor diversity. (Ref.1,2) The TCR gamma/delta heterodimer recognizes peptide antigen bound to MHC antigens, and subsequent signal transduction mediated by the invariant chains leads to T cell activation. (Ref.3) |
Synonyms | TCRG, TCRD, T-Cell Receptor gamma, T-Cell Receptor delta, T-Cell Receptor gamma delta |
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