Cd86 Rat Monoclonal Antibody [Clone ID: GL1]
CAT#: AM08053PU-N
Cd86 rat monoclonal antibody, clone GL1, Purified
Conjugation: APC Biotin FITC PE
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CNY 4,136.00
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Specifications
Product Data | |
Clone Name | GL1 |
Applications | FC, FN, IHC, IP |
Recommend Dilution | Flow Cytometry. (Ref.1-7) Immunoprecipitation. (Ref.1) Immunohistochemistry Frozen Sections. (Ref.6) Functional Assays: In vivo and In vitro blocking assays. (Ref.1,3,5) |
Reactivity | Mouse |
Host | Rat |
Clonality | Monoclonal |
Immunogen | LPS-activated mouse B cells.(Ref.1) |
Specificity | This antibody recognises CD86, the B7-2 co-stimulatory molecule and a ligand for CD28 and CD152/CTLA-4. The monoclonal antibody GL1 blocks mixed lymphocyte reactions and stimulation of T cells by antigen-presenting cells. (Ref.1,3,5) |
Formulation | 100 mM Borate Buffered Saline, pH 8.2. No preservatives or amine-containing buffer salts added. State: Purified State: Liquid purified Ig fraction. |
Concentration | lot specific |
Conjugation | Unconjugated |
Storage Condition | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Gene Name | CD86 antigen |
Database Link | |
Background | CD86 (also known as B7-2) is a type I transmembrane glycoprotein and a member of the immunoglobulin superfamily of cell surface receptors. It is expressed at high levels on resting peripheral monocytes and dendritic cells and at very low density on resting B and T lymphocytes. (Ref.1-5) CD86 expression is rapidly upregulated by B-cell specific stimuli with peak expression at 18-42 hours after stimulation. (Ref.1,5) CD86, along with CD80/B7-1, is an important accessory molecule in T cell costimulation via its interaction with CD28 and CD152/CTLA-4. Since CD86 has rapid kinetics of induction, it is believed to be the major CD28 ligand expressed early in the immune response. (Ref.1-9). |
Synonyms | CD28LG2, Activation B7-2 antigen, B70, BU63, B7.2, FUN-1 |
Reference Data |
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