CD49e / ITGA5 Rat Monoclonal Antibody [Clone ID: 5H10-27]
CAT#: AM08047LE-N
CD49e / ITGA5 rat monoclonal antibody, clone 5H10-27, Low Endotoxin
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CNY 5,071.00
货期*
4周
规格
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Specifications
Product Data | |
Clone Name | 5H10-27 |
Applications | FC, FN, IHC |
Recommend Dilution | Flow Cytometry. (Ref.1) Immunohistochemistry on Frozen Sections: (Ref.7) Functional Assays: In vitro blocking of adhesion. (Ref.1,2-4,6) T-cell co-stimulation. (Ref.3) |
Reactivity | Mouse |
Host | Rat |
Clonality | Monoclonal |
Immunogen | C57BL/6 x A/J F1 mouse mast cell line MC/9. (Ref.1) |
Specificity | This antibody is specific to alpha-5 subunit of the integrin alpha-5 beta-1 Fibronectin Receptor. It reacts with the alpha-5 chain (VLA-5) of the CD49e/CD29 heterodimeric Fibronectin Receptor. (Ref.1-5) Soluble 5H10-27 antibody inhibits VLA-5-mediated functions in vitro. (Ref.1,2-4,6) Immobilized 5H10-27 has also been demonstrated to co-stimulate the proliferative response of CD8+ T cells to plate-bound anti-CD3 monoclonal antibody. (Ref.3) |
Formulation | PBS containing no preservatives. State: Low Endotoxin State: Liquid purified Ig fraction. |
Concentration | lot specific |
Conjugation | Unconjugated |
Storage Condition | Store the antibody undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing. |
Gene Name | integrin alpha 5 (fibronectin receptor alpha) |
Database Link | |
Background | Integrin alpha 5 belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post translational cleavage in the extracellular domain to yield disulfide linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell surface mediated signalling. It is expressed on thymocytes, activated T cells, mast cells, and a variety of mouse cell lines. |
Synonyms | Integrin alpha-5, Fibronectin receptor subunit alpha, Integrin alpha-F, VLA-5, VLA5, FNRA |
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