CD45 / LCA Rat Monoclonal Antibody [Clone ID: I3/2.3]

Specifications

Product Data
Clone Name	I3/2.3
Applications	FC, IHC, IP, R
Recommend Dilution	Flow Cytometry. (Ref.4,5) Immunoprecipitation. (Ref.3,5) Immunohistochemistry on Frozen Sections. Radiometric Quantitation of CD45 molecules on cell surfaces. (Ref.3)
Reactivity	Mouse
Host	Rat
Clonality	Monoclonal
Specificity	This antibody recognizes a framework epitope present on all CD45 isoforms. (Ref.3-6)
Formulation	100 mM Borate Buffered Saline, pH 8.2. No preservatives or amine-containing buffer salts added. State: Purified State: Liquid purified Ig fraction.
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	protein tyrosine phosphatase, receptor type, C
Database Link	Entrez Gene 19264 Mouse UniProt ID P06800
Background	CD45 is a family of single chain transmembraneous glycoproteins consisting of at least four isoforms (220, 205, 190, 180 kDa) which share a common large intracellular domain. Their extracellular domains are heavily glycosylated. The different isoforms are produced by alternative messenger RNA splicing of three exons of a single gene on chromosome 1. CD45 is expressed on cells of the human hematopoietic lineage (including hematopoietic stem cells) with the exception of mature red cells. It is not detected on differentiated cells of other tissues. It is likely that CD45 plays an important role in signal transduction, inhibition or upregulation of various immunological functions. Antibodies recognising a common epitope on all of the isoforms are termed CD45 while those recognising only individual isoforms are termed CD45RA or CD45RO etc.
Synonyms	PTPRC, Leukocyte common antigen, L-CA, T200
Reference Data

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