Cd28 Hamster Monoclonal Antibody [Clone ID: 37.51]
CAT#: AM08037PU-N
Cd28 hamster monoclonal antibody, clone 37.51, Purified
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CNY 4,136.00
货期*
4周
规格
Cited in 11 publications. |
Product images
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Specifications
Product Data | |
Clone Name | 37.51 |
Applications | FC, FN, IP |
Recommend Dilution | Flow Cytometry (Ref.1,2). Immunoprecipitation (Ref.1). Functional Assay: In vitro costimulation of T cells and NK cells (Ref.1-3,7-9,11). |
Reactivity | Mouse |
Host | Hamster |
Clonality | Monoclonal |
Immunogen | C57BL/6N mouse T cell lymphoma EL-4 cell line. |
Specificity | This antibody is specific to CD28 costimulatory receptor (Mr. 40 kDa) |
Formulation | Borate Buffered Saline, pH 8.2. No preservatives or amine-containing buffer salts added. State: Purified State: Liquid purified Ig fraction. |
Concentration | lot specific |
Conjugation | Unconjugated |
Storage Condition | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Gene Name | CD28 antigen |
Database Link | |
Background | CD28 is a type I disulfide-linked homodimer that is constitutively expressed on most thymocytes, at low density on nearly all CD4+ and CD8+ peripheral T lymphocytes, and at very low levels on NK cells. Its expression is upregulated upon T-cell activation. (Ref.1-4) CD28 is a ligand for CD80/B7-1 and CD86/B7-2 on B cells and other antigen presenting cells, and plays an important role in the interaction between T cells and B cells. CD28 is a co-stimulatory receptor involved in many, but not all, T-cell independent immune responses. (Ref.5-8) |
Synonyms | TP44 |
Reference Data |
Citations (11)
The use of this Antibodies has been cited in the following citations: |
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CD8+ T-cells expressing interferon gamma or perforin play antagonistic roles in heart injury in experimental Trypanosoma cruzi-elicited cardiomyopathy
,Silverio JC, Pereira IR, Cipitelli Mda C, Vinagre NF, Rodrigues MM, Gazzinelli RT, Lannes-Vieira J,
PLoS Pathog.
,PubMed ID 22532799
[CD28]
|
Myeloid expression of angiotensin-converting enzyme facilitates myeloid maturation and inhibits the development of myeloid-derived suppressor cells
,Shen XZ, Okwan-Duodu D, Blackwell WL, Ong FS, Janjulia T, Bernstein EA, Fuchs S, Alkan S, Bernstein KE,
Lab. Invest.
,PubMed ID 24614194
[CD28]
|
Bcl6 controls granzyme B expression in effector CD8+ T cells
,Yoshida K, Sakamoto A, Yamashita K, Arguni E, Horigome S, Arima M, Hatano M, Seki N, Ichikawa T, Tokuhisa T,
Eur. J. Immunol.
,PubMed ID 17125145
[CD28]
|
Severe thymic atrophy in a mouse model of skin inflammation accounts for impaired TNFR1 signaling
,BelhacC)ne N, Gamas P, GonC'alvC(s D, Jacquin M, Beneteau M, Jacquel A, Colosetti P, Ricci JE, Wakkach A, Auberger P, Marchetti S,
PLoS ONE
,PubMed ID 23071785
[CD28]
|
Signal integration by Akt regulates CD8 T cell effector and memory differentiation
,Kim EH, Sullivan JA, Plisch EH, Tejera MM, Jatzek A, Choi KY, Suresh M,
J. Immunol.
,PubMed ID 22467649
[CD28]
|
Selective CD28 blockade attenuates acute and chronic rejection of murine cardiac allografts in a CTLA-4-dependent manner
,Zhang T, Fresnay S, Welty E, Sangrampurkar N, Rybak E, Zhou H, Cheng XF, Feng Q, Avon C, Laaris A, Whitters M, Nagelin AM, O'Hara RM, Azimzadeh AM,
Am. J. Transplant.
,PubMed ID 21749640
[CD28]
|
KSR1 modulates the sensitivity of mitogen-activated protein kinase pathway activation in T cells without altering fundamental system outputs
,Lin J, Harding A, Giurisato E, Shaw AS,
Mol. Cell. Biol.
,PubMed ID 19188442
[CD28]
|
Surface molecules that drive T cell development in vitro in the absence of thymic epithelium and in the absence of lineage-specific signals
,Cibotti R, Punt JA, Dash KS, Sharrow SO, Singer A,
Immunity
,PubMed ID 9075925
[CD28]
|
CD80 (B7.1) and CD54 (intracellular adhesion molecule-1) induce target cell susceptibility to promiscuous cytotoxic T cell lysis
,Nishio M, Spielman J, Lee RK, Nelson DL, Podack ER,
J. Immunol.
,PubMed ID 8906809
[CD28]
|
CD28-mediated costimulation is necessary for optimal proliferation of murine NK cells
,Nandi D, Gross JA, Allison JP,
J. Immunol.
,PubMed ID 7511644
[CD28]
|
Identification and distribution of the costimulatory receptor CD28 in the mouse
,Gross JA, Callas E, Allison JP,
J. Immunol.
,PubMed ID 1320641
[CD28]
|
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