CBL Mouse Monoclonal Antibody [Clone ID: 3B12]

Specifications

Product Data
Clone Name	3B12
Applications	ELISA, FC, IF, IHC, WB
Recommend Dilution	Western Blot: 1/500 - 1/2000. Immunohistochemistry on paraffin sections: 1/200 - 1/1000. Immunofluorescence: 1/200 - 1/1000. Flow cytometry: 1/200 - 1/400. ELISA: 1/10000.
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified recombinant fragment of human C-CBL expressed in E. Coli.
Specificity	This antibody reacts to C-CBL.
Formulation	State: Ascites State: Ascitic fluid containing 0.03% sodium azide.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Predicted Protein Size	120 kDa
Gene Name	Cbl proto-oncogene
Database Link	Entrez Gene 867 Human UniProt ID P22681
Background	The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation.
Synonyms	RING finger protein 55, CBL2, c-CBL
Reference Data

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