HIF-1 alpha (HIF1A) Mouse Monoclonal Antibody [Clone ID: 1A3]
CAT#: AM06608SU-N
HIF-1 alpha (HIF1A) mouse monoclonal antibody, clone 1A3, Ascites
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CNY 5,775.00
货期*
5周
规格
Cited in 2 publications. |
Specifications
Product Data | |
Clone Name | 1A3 |
Applications | ELISA, IF, IHC, WB |
Recommend Dilution | ELISA: 1/10000. Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. Immunohistochemistry on Paraffin Sections: 1/200 - 1/1000. |
Reactivity | Human, Monkey, Mouse |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | Purified recombinant fragment of Human HIF1A expressed in E. Coli. |
Specificity | Recognizes HIF1 alpha (HIF1A) |
Formulation | State: Ascites State: Ascitic fluid containing 0.03% Sodium Azide. |
Conjugation | Unconjugated |
Storage Condition | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Predicted Protein Size | 120 kDa |
Gene Name | hypoxia inducible factor 1 alpha subunit |
Database Link | |
Background | Hypoxia-inducible factor-1 (HIF1) is a transcription factor found in mammalian cells cultured under reduced oxygen tension that plays an essential role in cellular and systemic homeostatic responses to hypoxia. HIF1 is a heterodimer composed of an alpha subunit and a beta subunit. The beta subunit has been identified as the aryl hydrocarbon receptor nuclear translocator (ARNT). This gene encodes the alpha subunit of HIF-1. Overexpression of a natural antisense transcript (aHIF) of this gene has been shown to be associated with nonpapillary renal carcinomas. Two alternative transcripts encoding different isoforms have been identified. (provided by RefSeq) Tissue specificity: Expressed in most tissues with highest levels in kidney and heart. Overexpressed in the majority of common human cancers and their metastases, due to the presence of intratumoral hypoxia and as a result of mutations in genes encoding oncoproteins and tumor suppressors. |
Synonyms | HIF-1 alpha, Hypoxia-inducible factor 1 alpha, ARNT-interacting protein, Member of PAS protein 1, Basic-helix-loop-helix-PAS protein MOP1, BHLHE78 |
Reference Data |
Citations (2)
The use of this Antibodies has been cited in the following citations: |
---|
miR-335-laden B Cell-Derived Extracellular Vesicles Promote SOX4-Dependent Apoptosis in Human Multiple Myeloma Cells
,null,
Journal of Personalized Medicine
,PubMed ID 34945712
[HIF1A]
|
Correlation of hypoxia status with radiosensitizing effects of sodium glycididazole: A preclinical study
,null,
Oncology Letters
,PubMed ID 29616117
[HIF1A]
|
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